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Article

Novel functional hepatitis C virus glycoprotein isolates identified using an optimized viral pseudotype entry assay

6 Jul 2016

Abstract excerpt

Retrovirus pseudotypes are a highly tractable model used to study the entry pathways of enveloped viruses. This model has been extensively applied to the study of the hepatitis C virus (HCV) entry pathway, preclinical screening of antiviral antibodies and for assessing the phenotype of patient-derived viruses using HCV pseudoparticles (HCVpp) possessing the HCV E1 and E2 glycoproteins. However, not all...

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PMID: 27384448
DOI: 10.1099/jgv.0.000537

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