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Article

Fidaxomicin resistance in Clostridioides difficile: a systematic review and predictive modeling with RNA polymerase binding sites.

Antimicrobial agents and chemotherapy - 5 Dec 2024

Le ThanhPhuong M, Eubank Taryn A, McKelvey Ann M, Cao Xinyun, Hurdle Julian G, Garey Kevin W

Abstract excerpt

Fidaxomicin (FDX), an RNA polymerase (RNAP) inhibitor antibiotic, is a guideline-recommended therapy for Clostridioides difficile infection. Mutations associated with reduced FDX minimum inhibitory concentrations (MICs) have been identified. However, the molecular characterization of these mutations on FDX binding and the development of FDX resistance have not been studied. The purpose of this systematic review...

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Identifiers

PMID: 39503488
DOI: 10.1128/aac.01206-24
PMCID: PMC11619340

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