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Article

Rifaximin resistance in Clostridioides difficile is associated with specific rpoB alleles and multilocus sequence typing (MLST) clades.

BMC microbiology - 29 Jul 2025

Schwanbeck Julian, Laukien Friederike, Riedel Thomas, Bunk Boyke, Halama Philipp, Spröer Cathrin, Overmann Jörg, Cooper Paul, Kusumawati R Lia, Groß Uwe, Bohne Wolfgang, Zautner Andreas E

Abstract excerpt

BACKGROUND AND OBJECTIVES: Rifaximin (RFX) has recently been suggested as an alternative treatment option for Clostridioides difficile infection. This study reports the survey on RFX susceptibility within a C. difficile test cohort that represents the five clinically relevant phylogenetic clades. METHODS: Agar dilution assays were conducted to determine the minimum inhibitory concentrations (MICs) of RFX for 129...

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PMID: 40731265
DOI: 10.1186/s12866-025-04164-4
PMCID: PMC12306076

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