Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin.

doi:10.1038/s41586-024-08095-4

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Article

Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin.

Nature - 1 Nov 2024

Turner Adrianna M, Li Lucy, Monk Ian R, Lee Jean Y H, Ingle Danielle J, Portelli Stephanie, Sherry Norelle L, Isles Nicole, Seemann Torsten, Sharkey Liam K, Walsh Calum J, Reid Gavin E, Nie Shuai, Eijkelkamp Bart A, Holmes Natasha E, Collis Brennan, Vogrin Sara, Hiergeist Andreas, Weber Daniela, Gessner Andre, Holler Ernst, Ascher David B, Duchene Sebastian, Scott Nichollas E, Stinear Timothy P, Kwong Jason C, Gorrie Claire L, Howden Benjamin P, Carter Glen P

Abstract excerpt

Multidrug-resistant bacterial pathogens like vancomycin-resistant Enterococcus faecium (VREfm) are a critical threat to human health1. Daptomycin is a last-resort antibiotic for VREfm infections with a novel mode of action2, but for which resistance has been widely reported but is unexplained. Here we show that rifaximin, an unrelated antibiotic used prophylactically to prevent hepatic encephalopathy in patients...

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Identifiers

PMID: 39443798
DOI: 10.1038/s41586-024-08095-4
PMCID: PMC11602712

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