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Article

Crystal structure of truncated aspartate transcarbamoylase from Plasmodium falciparum.

Acta crystallographica. Section F, Structural biology communications - 1 Jul 2016

Lunev Sergey, Bosch Soraya S, Batista Fernando de Assis, Wrenger Carsten, Groves Matthew R

Abstract excerpt

The de novo pyrimidine-biosynthesis pathway of Plasmodium falciparum is a promising target for antimalarial drug discovery. The parasite requires a supply of purines and pyrimidines for growth and proliferation and is unable to take up pyrimidines from the host. Direct (or indirect) inhibition of de novo pyrimidine biosynthesis via dihydroorotate dehydrogenase (PfDHODH), the fourth enzyme of the pathway, has...

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Identifiers

PMID: 27380369
DOI: 10.1107/S2053230X16008475
PMCID: PMC4933002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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