Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The 14th Ile residue is essential for Leptin function in regulating energy homeostasis in rat.

Scientific reports - 5 Jul 2016

Xu Shuyang, Zhu Xianmin, Li Hong, Hu Youtian, Zhou Jinping, He Di, Feng Yun, Lu Lina, Du Guizhen, Hu Youjin, Liu Tiancheng, Wang Zhen, Ding Guohui, Chen Jiayu, Gao Shaorong, Wu Fang, Xue Zhigang, Li Yixue, Fan Guoping

Abstract excerpt

LEPTIN (LEP) is a circulating hormone released primarily from white adipocytes and is crucial for regulating satiety and energy homeostasis in humans and animals. Using the CRISPR technology, we created a set of Lep mutant rats that carry either null mutations or a deletion of the 14(th) Ile (LEP(∆I14)) in the mature LEP protein. We examined the potential off-target sites (OTS) by whole-genome high-throughput...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue
Share to CRISPR-Cas Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Energy Metabolism

Share to Homeostasis

Share to Isoleucine

Share to Leptin

Share to Mice, Obese

Share to Receptors, Leptin

Source

Open in PubMed Open full text

Identifiers

PMID: 27378381
DOI: 10.1038/srep28508
PMCID: PMC4932527

Genes

LEP
LEPR
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The 14th Ile residue is essential for Leptin function in regulating energy homeostasis in rat.PMID 27378381Read ↗

Leptin gene-targeted editing in ob/ob mouse adipose tissue based on the CRISPR/Cas9 systemSemantic proximity Read ↗

Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity.Semantic proximity Read ↗

A National Multicenter Study of Leptin and Leptin Receptor Deficiency and Systematic Review.Semantic proximity Read ↗

A quantitative pipeline to assess secretion of human leptin coding variants reveals mechanisms underlying leptin deficienciesSemantic proximity Read ↗

CRISPR-Cas9-mediated generation of obese and diabetic mouse models.Semantic proximity Read ↗

<i>Leptin</i> deficient rats develop nonalcoholic steatohepatitis with unique disease progressionSemantic proximity Read ↗

Prediction and Structural Comparison of Deleterious Coding Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) in Human LEP Gene Associated with Obesity.Semantic proximity Read ↗

Generation of obese rat model by transcription activator-like effector nucleases targeting the leptin receptor gene.Semantic proximity Read ↗

Uncovering the molecular mechanisms behind disease-associated leptin variants.Semantic proximity Read ↗

Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesitySemantic proximity Read ↗

The p. N103K mutation of leptin (LEP) gene and severe early onset obesity in Pakistan.Semantic proximity Read ↗

miRNA and leptin signaling in metabolic diseases and at extreme environmentsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.