Article
Analysis of maternal polymorphisms in arsenic (+3 oxidation state)-methyltransferase AS3MT and fetal sex in relation to arsenic metabolism and infant birth outcomes: Implications for risk analysis.
Reproductive toxicology (Elmsford, N.Y.) - 1 Jun 2016
Drobná Zuzana, Martin Elizabeth, Kim Kyung Su, Smeester Lisa, Bommarito Paige, Rubio-Andrade Marisela, García-Vargas Gonzalo G, Stýblo Miroslav, Zou Fei, Fry Rebecca C
Abstract excerpt
Arsenic (+3 oxidation state) methyltransferase (AS3MT) is the key enzyme in the metabolism of inorganic arsenic (iAs). Polymorphisms of AS3MT influence adverse health effects in adults, but little is known about their role in iAs metabolism in pregnant women and infants. The relationships between seven single nucleotide polymorphisms (SNPs) in AS3MT and urinary concentrations of iAs and its methylated metabolites...
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