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Piperacillin triggers virulence factor biosynthesis via the oxidative stress response in Burkholderia thailandensis

25 Jun 2021

Abstract excerpt

Significance Low-dose antibiotics can activate the expression of otherwise silent biosynthetic loci, but the mechanisms underlying this phenomenon are poorly understood. Our results reveal several classes of molecules that globally induce secondary metabolite biogenesis in the model bacterium Burkholderia thailandensis . We illuminate the mechanism of induction of one of these elicitors, the β-lactam...

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PMID: 34172579
DOI: 10.1073/pnas.2021483118

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