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Thailandenes, Cryptic Polyene Natural Products Isolated from Burkholderia thailandensis Using Phenotype-Guided Transposon Mutagenesis.

ACS chemical biology - 15 May 2020

Park Jong-Duk, Moon Kyuho, Miller Cheryl, Rose Jessica, Xu Fei, Ebmeier Christopher C, Jacobsen Jeremy R, Mao Dainan, Old William M, DeShazer David, Seyedsayamdost Mohammad R

Abstract excerpt

Burkholderia thailandensis has emerged as a model organism for investigating the production and regulation of diverse secondary metabolites. Most of the biosynthetic gene clusters encoded in B. thailandensis are silent, motivating the development of new methods for accessing their products. In the current work, we add to the canon of available approaches using phenotype-guided transposon mutagenesis to...

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Identifiers

PMID: 31816232
DOI: 10.1021/acschembio.9b00883
PMCID: PMC9106368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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