Discovery of scmR as a global regulator of secondary metabolism and virulence in Burkholderia thailandensis E264

Abstract excerpt

Significance Silent biosynthetic gene clusters represent fertile grounds for the discovery of new small molecules, and a number of approaches have been developed for activating them. Their regulation, however, has received far less attention, especially in Gram-negative bacteria. Here, we show that a LysR-type transcriptional regulator, which we name scmR , acts as a gatekeeper of secondary metabolism and...

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