Article
A polygenic risk score for multiple myeloma risk prediction.
European journal of human genetics : EJHG - 1 Apr 2022
Canzian Federico, Piredda Chiara, Macauda Angelica, Zawirska Daria, Andersen Niels Frost, Nagler Arnon, Zaucha Jan Maciej, Mazur Grzegorz, Dumontet Charles, Wątek Marzena, Jamroziak Krzysztof, Sainz Juan, Várkonyi Judit, Butrym Aleksandra, Beider Katia, Abildgaard Niels, Lesueur Fabienne, Dudziński Marek, Vangsted Annette Juul, Pelosini Matteo, Subocz Edyta, Petrini Mario, Buda Gabriele, Raźny Małgorzata, Gemignani Federica, Marques Herlander, Orciuolo Enrico, Kadar Katalin, Jurczyszyn Artur, Druzd-Sitek Agnieszka, Vogel Ulla, Andersen Vibeke, Reis Rui Manuel, Suska Anna, Avet-Loiseau Hervé, Kruszewski Marcin, Tomczak Waldemar, Rymko Marcin, Minvielle Stephane, Campa Daniele
Abstract excerpt
There is overwhelming epidemiologic evidence that the risk of multiple myeloma (MM) has a solid genetic background. Genome-wide association studies (GWAS) have identified 23 risk loci that contribute to the genetic susceptibility of MM, but have low individual penetrance. Combining the SNPs in a polygenic risk score (PRS) is a possible approach to improve their usefulness. Using 2361 MM cases and 1415 controls...
Topics
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Multiple Myeloma
- Polymorphism, Single Nucleotide
- Risk Factors