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A Comparison between Low- and High-Passage Strains of Human Cytomegalovirus.

Journal of microbiology and biotechnology - 28 Oct 2016

Wang Wen-Dan, Lee Gyu-Cheol, Kim Yu Young, Lee Chan Hee

Abstract excerpt

To understand how human cytomegalovirus (HCMV) might change and evolve after reactivation, it is very important to understand how the nucleotide sequence of cultured HCMV changes after in vitro passaging in cell culture, and how these changes affect the genome of HCMV and the consequent variation in amino acid sequence. Strain JHC of HCMV was propagated in vitro for more than 40 passages and its biological and...

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PMID: 27363474
DOI: 10.4014/jmb.1604.04045

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