Article
The posterior HOXD locus: Its contribution to phenotype and malignancy of Ewing sarcoma.
Oncotarget - 5 Jul 2016
von Heyking Kristina, Roth Laura, Ertl Miriam, Schmidt Oxana, Calzada-Wack Julia, Neff Frauke, Lawlor Elizabeth R, Burdach Stefan, Richter Guenther Hs
Abstract excerpt
Microarray analysis revealed genes of the posterior HOXD locus normally involved in bone formation to be over-expressed in primary Ewing sarcoma (ES). The expression of posterior HOXD genes was not influenced via ES pathognomonic EWS/ETS translocations. However, knock down of the dickkopf WNT signaling pathway inhibitor 2 (DKK2) resulted in a significant suppression of HOXD10, HOXD11 and HOXD13 while...
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