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Article

The endochondral bone protein CHM1 sustains an undifferentiated, invasive phenotype, promoting lung metastasis in Ewing sarcoma.

Molecular oncology - 1 Sept 2017

von Heyking Kristina, Calzada-Wack Julia, Göllner Stefanie, Neff Frauke, Schmidt Oxana, Hensel Tim, Schirmer David, Fasan Annette, Esposito Irene, Müller-Tidow Carsten, Sorensen Poul H, Burdach Stefan, Richter Günther H S

Abstract excerpt

Ewing sarcomas (ES) are highly malignant, osteolytic bone or soft tissue tumors, which are characterized by EWS-ETS translocations and early metastasis to lung and bone. In this study, we investigated the role of the BRICHOS chaperone domain-containing endochondral bone protein chondromodulin I (CHM1) in ES pathogenesis. CHM1 is significantly overexpressed in ES, and chromosome immunoprecipitation (ChIP) data...

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Share to Cell Proliferation
Share to Chondrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelial Cells

Share to Gene Expression Regulation, Neoplastic

Share to Intercellular Signaling Peptides and Proteins

Share to Mice, Inbred BALB C

Share to Neoplasm Invasiveness

Share to Sarcoma, Ewing

Source

Open in PubMed Open full text

Identifiers

PMID: 28319320
DOI: 10.1002/1878-0261.12057
PMCID: PMC5579336

Genes

FLI1
JAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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