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Article

EWS/ETS Regulates the Expression of the Dickkopf Family in Ewing Family Tumor Cells

27 Feb 2009

Abstract excerpt

BACKGROUND: The Dickkopf (DKK) family comprises a set of proteins that function as regulators of Wnt/beta-catenin signaling and has a crucial role in development. Recent studies have revealed the involvement of this family in tumorigenesis, however their role in tumorigenesis is still remained unclear. METHODOLOGY/PRINCIPAL FINDINGS: We found increased expression of DKK2 but decreased expression of DKK1 in Ewing...

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PMID: 19247449
DOI: 10.1371/journal.pone.0004634

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