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Article

KinMutRF: a random forest classifier of sequence variants in the human protein kinase superfamily.

BMC genomics - 23 Jun 2016

Pons Tirso, Vazquez Miguel, Matey-Hernandez María Luisa, Brunak Søren, Valencia Alfonso, Izarzugaza Jose Mg

Abstract excerpt

BACKGROUND: The association between aberrant signal processing by protein kinases and human diseases such as cancer was established long time ago. However, understanding the link between sequence variants in the protein kinase superfamily and the mechanistic complex traits at the molecular level remains challenging: cells tolerate most genomic alterations and only a minor fraction disrupt molecular function...

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Identifiers

PMID: 27357839
DOI: 10.1186/s12864-016-2723-1
PMCID: PMC4928150

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BTK
MCC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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