Article
RNA is favourable for analysing EGFR mutations in malignant pleural effusion of lung cancer.
The European respiratory journal - 1 Mar 2012
Tsai T-H, Su K-Y, Wu S-G, Chang Y-L, Luo S-C, Jan I-S, Yu C-J, Yu S-L, Shih J-Y, Yang P-C
Abstract excerpt
Malignant pleural effusion (MPE) is a useful specimen allowing for the evaluation of EGFR status in nonsmall cell lung cancer (NSCLC). However, direct sequencing of genomic DNA from MPE samples was found not to be sensitive for EGFR mutation detection. To test whether EGFR analysis from RNA is less prone to interference from nontumour cells that have no or lower EGFR expression, we compared three methods...
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