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p38α Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress.

Cell stem cell - 4 Aug 2016

Karigane Daiki, Kobayashi Hiroshi, Morikawa Takayuki, Ootomo Yukako, Sakai Mashito, Nagamatsu Go, Kubota Yoshiaki, Goda Nobuhito, Matsumoto Michihiro, Nishimura Emi K, Soga Tomoyoshi, Otsu Kinya, Suematsu Makoto, Okamoto Shinichiro, Suda Toshio, Takubo Keiyo

Abstract excerpt

Hematopoietic stem cells (HSCs) maintain quiescence by activating specific metabolic pathways, including glycolysis. We do not yet have a clear understanding of how this metabolic activity changes during stress hematopoiesis, such as bone marrow transplantation. Here, we report a critical role for the p38MAPK family isoform p38α in initiating hematopoietic stem and progenitor cell (HSPC) proliferation during...

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Identifiers

PMID: 27345838
DOI: 10.1016/j.stem.2016.05.013

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