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Article

Adaptive and Pathogenic Responses to Stress by Stem Cells during Development

10 Dec 2012

Abstract excerpt

Cellular stress is the basis of a dose-dependent continuum of responses leading to adaptive health or pathogenesis. For all cells, stress leads to reduction in macromolecular synthesis by shared pathways and tissue and stress-specific homeostatic mechanisms. For stem cells during embryonic, fetal, and placental development, higher exposures of stress lead to decreased anabolism, macromolecular synthesis and cell...

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PMID: 24710551
DOI: 10.3390/cells1041197

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