Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CCR4-associated factor CAF1 is an essential factor for spermatogenesis.

Molecular and cellular biology - 1 Jul 2004

Berthet Cyril, Morera Anne-Marie, Asensio Marie-Jeanne, Chauvin Marie-Agnes, Morel Anne-Pierre, Dijoud Frederique, Magaud Jean-Pierre, Durand Philippe, Rouault Jean-Pierre

Abstract excerpt

The CCR4-associated protein CAF1 has been demonstrated to play several roles in the control of transcription and of mRNA decay. To gain further insight into its physiological function, we generated CAF1-deficient mice. They are viable, healthy, and normal in appearance; however, mCAF1(-/-) male mice are sterile. The crossing of mCAF1(+/-) mice gave a Mendelian ratio of mCAF1(+/+), mCAF1(+/-), and mCAF1(-/-) pups,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Spermatogenesis
Share to Exoribonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ Cells

Share to Haploidy

Share to Infertility, Male

Share to Ribonucleases

Share to Seminiferous Tubules

Share to Sertoli Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 15199137
DOI: 10.1128/MCB.24.13.5808-5820.2004
PMCID: PMC480892

Genes

CCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CCR4-associated factor CAF1 is an essential factor for spermatogenesis.PMID 15199137Read ↗

Inactivation of CUG-BP1/CELF1 causes growth, viability, and spermatogenesis defects in mice.Semantic proximity Read ↗

Meiosis I arrest abnormalities lead to severe oligozoospermia in meiosis 1 arresting protein (M1ap)-deficient mice.Semantic proximity Read ↗

MARF1 regulates essential oogenic processes in mice.Semantic proximity Read ↗

Ccer1 is a spermatid-specific gene required for spermatogenesis and male fertilitySemantic proximity Read ↗

CIB4 is essential for the haploid phase of spermatogenesis in mice†Semantic proximity Read ↗

CIB1 Is Essential for Mouse SpermatogenesisSemantic proximity Read ↗

Germ cell expression of the transcriptional co-repressor TIF1β is required for the maintenance of spermatogenesis in the mouseSemantic proximity Read ↗

TAF4b is Required for Mouse Spermatogonial Stem Cell DevelopmentSemantic proximity Read ↗

C. elegans homologue of the Caf1 gene, which encodes a subunit of the CCR4-NOT complex, is essential for embryonic and larval development and for meiotic progressionSemantic proximity Read ↗

Claudin 11 deficiency in mice results in loss of the Sertoli cell epithelial phenotype in the testis.Semantic proximity Read ↗

E4 Transcription Factor 1 (E4F1) Regulates Sertoli Cell Proliferation and Fertility in MiceSemantic proximity Read ↗

A novel acrosomal protein, IQCF 1, involved in sperm capacitation and the acrosome reactionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.