Article
The significance of BRAF V600E mutation status discordance between primary cutaneous melanoma and brain metastases: The implications for BRAF inhibitor therapy.
Medicine - 1 Dec 2017
Hannan Enda J, O'Leary Donal P, MacNally Stephen P, Kay Elaine W, Farrell Michael A, Morris Patrick G, Power Colm P, Hill Arnold D K
Abstract excerpt
To compare BRAF V600E status of primary melanoma and brain metastases to assess for discordance by cross-sectional study, and to evaluate clinical implications on BRAF inhibitor therapy.Brain metastases are common in patients with advanced melanoma. Between 40% and 60% of melanomas demonstrate BRAF mutations, BRAF V600E being most common. Selective BRAF inhibitor therapy has shown improvement in outcome in...
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