Article
Genetic and clinical biomarkers of tocilizumab response in patients with rheumatoid arthritis.
Pharmacological research - 1 Sept 2016
Maldonado-Montoro Mar, Cañadas-Garre Marisa, González-Utrilla Alfonso, Plaza-Plaza José Cristian, Calleja-Hernández Miguel Ÿngel
Abstract excerpt
The aim of this study was to investigate the influence of clinical and genetic factors on response to tocilizumab (TCZ) response, remission, low disease activity (LDA) and DAS28 improvement. A retrospective cohort study in 79 RA patients treated with TCZ during 6/18 months of therapy was conducted. CD69(rs11052877), GALNT18(rs4910008), CLEC2D(rs1560011), KCNMB1(rs703505), ENOX1(rs9594987), , and...