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Interleukin-6-receptor polymorphisms rs12083537, rs2228145, and rs4329505 as predictors of response to tocilizumab in rheumatoid arthritis.

Pharmacogenetics and genomics - 1 Aug 2014

Enevold Christian, Baslund Bo, Linde Louise, Josephsen Norah L, Tarp Ulrik, Lindegaard Hanne, Jacobsen Søren, Nielsen Claus H

Abstract excerpt

Tocilizumab (TCZ), a monoclonal antibody targeting the human interleukin-6-receptor (IL-6R), is indicated for the treatment of rheumatoid arthritis (RA). We examined whether three IL6R single-nucleotide polymorphisms rs12083537, rs2228145 (formerly rs8192284), and rs4329505 with previously reported functional effects were associated with clinical response to TCZ in a retrospective study cohort consisting of 79 RA...

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Share to Aged, 80 and over
Share to Alleles
Share to Antibodies, Monoclonal, Humanized
Share to Antirheumatic Agents
Share to Arthritis, Rheumatoid
Share to Haplotypes
Share to Receptors, Interleukin-6
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PMID: 24978393
DOI: 10.1097/FPC.0000000000000071

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CRP

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