Article
α7 Nicotinic Acetylcholine Receptor Relieves Angiotensin II-Induced Senescence in Vascular Smooth Muscle Cells by Raising Nicotinamide Adenine Dinucleotide-Dependent SIRT1 Activity.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2016
Li Dong-Jie, Huang Fang, Ni Min, Fu Hui, Zhang Liang-Sheng, Shen Fu-Ming
Abstract excerpt
OBJECTIVE: α7 nicotinic acetylcholine receptor (α7nAChR) is a subtype of nAChR and has been reported to be involved in hypertension end-organ damage. In this study, we tested the role of α7nAChR in angiotensin II (Ang II)-induced senescence of vascular smooth muscle cells (VSMCs). APPROACH AND RESULTS: Expression of α7nAChR was not influenced by Ang II. Ang II induced remarkable senescent phenotypes in rodent and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.