Article
The P2Y2 nucleotide receptor is an inhibitor of vascular calcification.
Atherosclerosis - 1 Feb 2017
Qian Shaomin, Regan Jenna N, Shelton Maxwell T, Hoggatt April, Mohammad Khalid S, Herring Paul B, Seye Cheikh I
Abstract excerpt
BACKGROUND AND AIMS: Mutations in the 5'-nucleotidase ecto (NT5E) gene that encodes CD73, a nucleotidase that converts AMP to adenosine, are linked to arterial calcification. However, the role of purinergic receptor signaling in the pathology of intimal calcification is not well understood. In this study, we examined whether extracellular nucleotides acting via P2Y2 receptor (P2Y2R) modulate arterial intimal...
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