Article
Influenza A(H1N1)pdm09 virus exhibiting enhanced cross-resistance to oseltamivir and peramivir due to a dual H275Y/G147R substitution, Japan, March 2016.
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin - 16 Jun 2016
Takashita Emi, Fujisaki Seiichiro, Shirakura Masayuki, Nakamura Kazuya, Kishida Noriko, Kuwahara Tomoko, Shimazu Yukie, Shimomura Takeshi, Watanabe Shinji, Odagiri Takato
Abstract excerpt
An influenza A(H1N1)pdm09 virus carrying a G147R substitution in combination with an H275Y substitution in the neuraminidase protein, which confers cross-resistance to oseltamivir and peramivir, was detected from an immunocompromised inpatient in Japan, March 2016. This dual H275Y/G147R mutant virus exhibited enhanced cross-resistance to both drugs compared with the single H275Y mutant virus and reduced...
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