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Article

Reassortment and mutations associated with emergence and spread of oseltamivir-resistant seasonal influenza A/H1N1 viruses in 2005-2009.

PloS one - 31 Mar 2011

Yang Ji-Rong, Lin Yu-Cheng, Huang Yuan-Pin, Su Chun-Hui, Lo Je, Ho Yu-Lin, Yao Ching-Yuan, Hsu Li-Ching, Wu Ho-Sheng, Liu Ming-Tsan

Abstract excerpt

A dramatic increase in the frequency of the H275Y mutation in the neuraminidase (NA), conferring resistance to oseltamivir, has been detected in human seasonal influenza A/H1N1 viruses since the influenza season of 2007-2008. The resistant viruses emerged in the ratio of 14.3% and quickly reached 100% in Taiwan from September to December 2008. To explore the mechanisms responsible for emergence and spread of the...

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Identifiers

PMID: 21483816
DOI: 10.1371/journal.pone.0018177
PMCID: PMC3069057

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