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Article

Increase of Synergistic Secondary Antiviral Mutations in the Evolution of A(H1N1)pdm09 Influenza Virus Neuraminidases.

Viruses - 11 Jul 2024

Duwe Susanne C, Milde Jeanette, Heider Alla, Wedde Marianne, Schweiger Brunhilde, Dürrwald Ralf

Abstract excerpt

The unexpected emergence of oseltamivir-resistant A(H1N1) viruses in 2008 was facilitated in part by the establishment of permissive secondary neuraminidase (NA) substitutions that compensated for the fitness loss due to the NA-H275Y resistance substitution. These viruses were replaced in 2009 by oseltamivir-susceptible A(H1N1)pdm09 influenza viruses. Genetic analysis and screening of A(H1N1)pdm09 viruses...

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Identifiers

PMID: 39066271
DOI: 10.3390/v16071109
PMCID: PMC11281601

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