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Article

CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease

1 Jan 2011

Abstract excerpt

Disturbed circadian rhythms with sleep problems and disrupted diurnal activity are often seen in patients suffering from Alzheimer disease (AD). Both endogenous CLOCK genes and external Zeitgeber are responsible for the maintenance of circadian rhythmicity in humans. Therefore, modifications of the internal CLOCK system and its interactions with exogenous factors might constitute the neurobiological basis for...

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Identifiers

PMID: 22028968
DOI: 10.4061/2011/383091

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