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Article

Tyrosine phosphatase SHP-2 regulates IL-1 signaling in fibroblasts through focal adhesions.

Journal of cellular physiology - 1 Apr 2006

Herrera Abreu Maria Teresa, Wang Qin, Vachon Eric, Suzuki Tomoko, Chow Chung-Wai, Wang Yingchun, Hong Ouyang, Villar Jesús, McCulloch Christopher A G, Downey Gregory P

Abstract excerpt

Interleukin-1beta (IL-1beta) mediates destruction of matrix collagens in diverse inflammatory diseases including arthritis, periodontitis, and pulmonary fibrosis by activating fibroblasts, cells that interact with matrix proteins through integrin-based adhesions. In vitro, IL-1beta signaling is modulated by focal adhesions, supramolecular protein complexes that are enriched with tyrosine kinases and phosphatases....

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Source

Identifiers

PMID: 16250012
DOI: 10.1002/jcp.20544

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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