Article
MUFFINN: cancer gene discovery via network analysis of somatic mutation data.
Genome biology - 23 Jun 2016
Cho Ara, Shim Jung Eun, Kim Eiru, Supek Fran, Lehner Ben, Lee Insuk
Abstract excerpt
A major challenge for distinguishing cancer-causing driver mutations from inconsequential passenger mutations is the long-tail of infrequently mutated genes in cancer genomes. Here, we present and evaluate a method for prioritizing cancer genes accounting not only for mutations in individual genes but also in their neighbors in functional networks, MUFFINN (MUtations For Functional Impact on Network Neighbors)....
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