Article
The early activation of memory B cells from Wiskott-Aldrich syndrome patients is suppressed by CD19 downregulation.
Blood - 29 Sept 2016
Bai Xiaoming, Zhang Yongjie, Huang Lu, Wang Jinzhi, Li Wenyan, Niu Linlin, Jiang Hongyan, Dai Rongxin, Zhou Lina, Zhang Zhiyong, Miller Heather, Song Wenxia, Zhao Xiaodong, Liu Chaohong
Abstract excerpt
Wiskott-Aldrich syndrome (WAS) pediatric patients exhibit a deficiency in humoral immune memory. However, the mechanism by which Wiskott-Aldrich syndrome protein (WASP) regulates the differentiation and activation of memory B cells remains elusive. Here we examine the early activation events of memory B cells from the peripheral blood mononuclear cells of WAS patients and age-matched healthy controls (HCs) using...
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