Article
CD20 as a gatekeeper of the resting stage of human B cells
2020-07-31
Abstract excerpt
CD20 is a B cell specific membrane protein and a target of therapeutic antibodies such as rituximab (RTX) 1 . In spite of the prominent usage of anti-CD20 antibodies in the clinic little is known about the biological function of CD20 2 . Here we show that CD20 controls the nanoscale organization of receptors on the surface of resting B lymphocytes. A CRISPR/Cas-based ablation of CD20 in Ramos B cells results in...
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Identifiers and source
- Literature Corpus work
- db3a75ee-c178-573c-a9db-b8b38f43bd9e
- DOI
- 10.1101/2020.07.31.230110