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A genome-wide association study in Caucasian women suggests the involvement of HLA genes in the severity of facial solar lentigines.

Pigment cell & melanoma research - 1 Sept 2016

Laville Vincent, Clerc Sigrid Le, Ezzedine Khaled, Jdid Randa, Taing Lieng, Labib Taoufik, Coulonges Cedric, Ulveling Damien, Carpentier Wassila, Galan Pilar, Hercberg Serge, Morizot Frederique, Latreille Julie, Malvy Denis, Tschachler Erwin, Zagury Jean-François

Abstract excerpt

Solar lentigines are a common feature of sun-induced skin ageing. Little is known, however, about the genetic factors contributing to their development. In this genome-wide association study, we aimed to identify genetic loci associated with solar lentigines on the face in 502 middle-aged French women. Nine SNPs, gathered in two independent blocks on chromosome 6, exhibited a false discovery rate below 25% when...

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PMID: 27327535
DOI: 10.1111/pcmr.12502

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MITF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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