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Article

A genome-wide association study identifies that SAMD5 interacts with regular Sun exposure to influence nasolabial folds development.

Journal of physiological anthropology - 28 Feb 2026

Ng Jun Yan, Sio Yang Yie, Chew Fook Tim

Abstract excerpt

BACKGROUND: Skin ageing is influenced by genetics, chronological age, and Sun exposure. Nasolabial folds are wrinkles prevalent among young ethnic Chinese participants in the Singapore/Malaysia Cross-sectional Genetics Epidemiology Study (SMCGES). METHODS: We analysed data from 4421 SMCGES ethnic Chinese young adults. Collected data included demographics, Sun exposure, Fitzpatrick Skin Type, and nasolabial fold...

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Identifiers

PMID: 41764564
DOI: 10.1186/s40101-026-00423-z
PMCID: PMC13059621

Genes

SAMD5
NES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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