Article
A genome-wide association study in Caucasian women points out a putative role of the STXBP5L gene in facial photoaging.
The Journal of investigative dermatology - 1 Apr 2013
Le Clerc Sigrid, Taing Lieng, Ezzedine Khaled, Latreille Julie, Delaneau Olivier, Labib Toufik, Coulonges Cédric, Bernard Anne, Melak Safa, Carpentier Wassila, Malvy Denis, Jdid Randa, Galan Pilar, Hercberg Serge, Morizot Frederique, Guinot Christiane, Tschachler Erwin, Zagury Jean F
Abstract excerpt
A genome-wide association study (GWAS) was conducted on 502 French middle-aged Caucasian women to identify genetic factors that may affect skin aging severity. A high-throughput Illumina Human Omni1-Quad beadchip was used. After single-nucleotide polymorphism (SNP) quality controls, 795,063 SNPs remained for analysis purposes. Possible stratification was first examined using the Eigenstrat method, and then the...
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