Epistasis of ERAP1 With 4 Major Histocompatibility Complex Class I Alleles in Frontal Fibrosing Alopecia: A Genome-Wide Association Study Meta-Analysis.

doi:10.1001/jamadermatol.2024.6434

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Article

Epistasis of ERAP1 With 4 Major Histocompatibility Complex Class I Alleles in Frontal Fibrosing Alopecia: A Genome-Wide Association Study Meta-Analysis.

JAMA dermatology - 1 Mar 2025

Rayinda Tuntas, Dand Nick, McSweeney Sheila M, Christou Evangelos, Ung Chuin Ying, Stefanato Catherine M, Fenton David A, Harries Matthew, Palamaras Ioulios, Tidman Alice, Holmes Susan, Koutalopoulou Anastasia, Ardern-Jones Michael, Kaur Manjit, Papanikou Sofia, Chasapi Vasiliki, Vañó-Galvan Sergio, Saceda-Corralo David, Melián-Olivera Ana, Azcarraga-Llobet Carlos, Lobato-Berezo Alejandro, Bustamante Mariona, Sunyer Jordi, Starace Michela Valeria Rita, Piraccini Bianca Maria, Wiss Isabel Pupo, Senna Maryanne Makredes, Singh Rashmi, Hillmann Kathrin, Kanti-Schmidt Varvara, Blume-Peytavi Ulrike, McGrath John A, Simpson Michael A, Tziotzios Christos

Abstract excerpt

Importance: Frontal fibrosing alopecia (FFA) is an inflammatory and scarring form of hair loss of increasing prevalence that most commonly affects women. An improved understanding of the genetic basis of FFA will support the identification of pathogenic mechanisms and therapeutic targets. Objective: To identify novel genomic loci at which common genetic variation affects FFA susceptibility and assess nonadditive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39937552
DOI: 10.1001/jamadermatol.2024.6434
PMCID: PMC11822599

Genes

ERAP1

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