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Article

l-Cys/CSE/H2S pathway modulates mouse uterus motility and sildenafil effect.

Pharmacological research - 1 Sept 2016

Mitidieri Emma, Tramontano Teresa, Donnarumma Erminia, Brancaleone Vincenzo, Cirino Giuseppe, D Emmanuele di Villa Bianca Roberta, Sorrentino Raffaella

Abstract excerpt

Sildenafil, a selective phosphodiesterase type 5 (PDE5) inhibitor, commonly used in the oral treatment for erectile dysfunction, relaxes smooth muscle of human bladder through the activation of hydrogen sulfide (H2S) signaling. H2S is an endogenous gaseous transmitter with myorelaxant properties predominantly formed from l-cysteine (l-Cys) by cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE)....

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Identifiers

PMID: 27326921
DOI: 10.1016/j.phrs.2016.06.017

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CBS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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