Article
Evaluation of Tumor DNA Sequencing Results in Patients with Gastric and Gastroesophageal Junction Adenocarcinoma Stratified by TP53 Mutation Status.
The oncologist - 5 Apr 2022
Wood Anthony C, Zhang Yonghong, Mo Qianxing, Cen Ling, Fontaine Jacques, Hoffe Sarah E, Frakes Jessica, Dineen Sean P, Pimiento Jose M, Walko Christine M, Mehta Rutika
Abstract excerpt
BACKGROUND: Gastric cancer (GC) and gastroesophageal junction adenocarcinomas (GEJ) are molecularly diverse. TP53 is the most frequently altered gene with approximately 50% of patients harboring mutations. This qualitative study describes the distinct genomic alterations in GCs and GEJs stratified by TP53 mutation status. PATIENTS AND METHODS: Tumor DNA sequencing results of 324 genes from 3741 patients with GC...
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