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The emerging role of bexarotene in the treatment of Alzheimer&rsquo;s disease: current evidence

1 Feb 2015

Abstract excerpt

In 2012, a novel approach to the treatment of Alzheimer's disease was introduced, heralding a wave of excitement in the field of dementia. Bexarotene, a retinoid X receptor agonist, was shown to reverse neurodegeneration, improve cognition, and decrease levels of amyloid-β in transgenic mice expressing familial Alzheimer disease mutations. Since then, there has been widespread discussion about bexarotene, as well...

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PMID: 25709453
DOI: 10.2147/ndt.s61309

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