Article
Dyes as bifunctional markers of DNA hybridization on surfaces and mutation detection.
Bioelectrochemistry (Amsterdam, Netherlands) - 1 Oct 2016
García-Mendiola Tania, Cerro María Ramos, López-Moreno José María, Pariente Félix, Lorenzo Encarnación
Abstract excerpt
The interaction of small molecules with DNA has found diagnostic and therapeutic applications. In this work, we propose the use of two different dyes, in particular Azure A and Safranine, as bifunctional markers of on-surface DNA hybridization and potent tools for screening of specific gene mutations directly in real DNA PCR amplicons extracted from blood cells. By combining spectroscopic and electrochemical...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
