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Article

Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling.

Autophagy - 1 Sept 2016

Choi Hyowon, Merceron Christophe, Mangiavini Laura, Seifert Erin L, Schipani Ernestina, Shapiro Irving M, Risbud Makarand V

Abstract excerpt

Nucleus pulposus (NP) cells reside in the avascular and hypoxic microenvironment of intervertebral discs. Importantly, many activities related to survival and function of NP cells are controlled by the HIF-family of transcription factors. We hypothesize that NP cells adapt to their hypoxic niche through modulation of macroautophagy/autophagy. In various cell types, hypoxia induces autophagy in a HIF1A-dependent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 27314664
DOI: 10.1080/15548627.2016.1192753
PMCID: PMC5082780

Genes

MTOR
ATG12
ATG5
BECN1
BNIP3
ULK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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