A novel and effective approach to generate germline-like monoclonal antibodies by integration of phage and mammalian cell display platforms

Abstract excerpt

Phage display technology allows for rapid selection of antibodies from the large repertoire of human antibody fragments displayed on phages. However, antibody fragments should be converted to IgG for biological characterizations and affinity of antibodies obtained from phage display library is frequently not sufficient for efficient use in clinical settings. Here, we describe a new approach that combines phage...

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