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ATRX immunostaining predicts IDH and H3F3A status in gliomas

16 Jun 2016

Abstract excerpt

Gliomas are the most frequent intraaxial CNS neoplasms with a heterogeneous molecular background. Recent studies on diffuse gliomas have shown frequent alterations in the genes involved in chromatin remodelling pathways such as α-thalassemia/mental-retardation-syndrome-X-linked gene (ATRX). Yet, the reliability of ATRX in predicting isocitrate dehydrogenase (IDH) and H3 histone, family 3A (H3F3A) mutations in...

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PMID: 27311324
DOI: 10.1186/s40478-016-0331-6

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