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Article

Associations of phenotypic age acceleration, genetic risk, and lifestyle with chronic digestive diseases: A large-scale longitudinal cohort study.

The journal of nutrition, health & aging - 1 Feb 2026

Xiang Shuai, Li Yixuan, Li Yunlong, Xie Shuzhe, Wang Chengfeng, Che Xu, Du Yongxing

Abstract excerpt

BACKGROUND: Phenotypic age acceleration (PhenoAgeAccel) is a promising biological aging metric, but its associations with chronic digestive disease risk are unclear. This study evaluated these associations and assessed modification by genetic risk and lifestyle. METHODS: We analyzed 292,639 UK Biobank participants. PhenoAge and PhenoAgeAccel were calculated using a validated algorithm based on clinical...

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Identifiers

PMID: 41534122
DOI: 10.1016/j.jnha.2026.100775
PMCID: PMC12835587

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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