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Ataxia telangiectasia and Rad3-related inhibitors and cancer therapy: where we stand

24 Apr 2019

Abstract excerpt

BACKGROUND: The ataxia telangiectasia and Rad3-related (ATR) checkpoint kinase 1 (CHK1) pathway plays an essential role in suppressing replication stress from DNA damage and oncogene activation. MAIN BODY: Preclinical studies have shown that cancer cells with defective DNA repair mechanisms or cell cycle checkpoints may be particularly sensitive to ATR inhibitors. Preclinical and clinical data from early-phase...

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PMID: 31018854
DOI: 10.1186/s13045-019-0733-6

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