Article
EXPRESS: NGF-trkA signaling modulates the analgesic effects of prostatic acid phosphatase in resiniferatoxin-induced neuropathy.
Molecular pain - 1 Jan 2016
Wu Chieh-Hsin, Ho Wan-Yi, Lee Yi-Chen, Lin Chih-Lung, Hsieh Yu-Lin
Abstract excerpt
BACKGROUND: Neuropathic pain in small-fiber neuropathy results from injury to and sensitization of nociceptors. Functional prostatic acid phosphatase (PAP) acts as an analgesic effector. However, the mechanism responsible for the modulation of PAP neuropathology, which leads to loss of the analgesic effect after small-fiber neuropathy, remains unclear. RESULTS: We used a resiniferatoxin (RTX)-induced small-fiber...
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