Article
Genetic Association Analysis Reveals Differences in the Contribution of NOD2 Variants to the Clinical Phenotypes of Orofacial Granulomatosis.
Inflammatory bowel diseases - 1 Jul 2016
Mentzer Alexander, Nayee Shalini, Omar Yasmin, Hullah Esther, Taylor Kirstin, Goel Rishi, Bye Hannah, Shembesh Tarik, Elliott Timothy R, Campbell Helen, Patel Pritash, Nolan Anita, Mansfield John, Challacombe Stephen, Escudier Michael, Mathew Christopher G, Sanderson Jeremy D, Prescott Natalie J
Abstract excerpt
BACKGROUND: Orofacial granulomatosis (OFG) is a rare, inflammatory disorder of the mouth, in which some patients also have intestinal Crohn's disease (CD). The etiology remains largely unknown, although there is a high prevalence of atopy, and oral granulomas are also seen in other immune disorders particularly CD and sarcoidosis. We investigated whether genetic variants associated with an increased risk of CD,...
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