Orofacial granulomatosis associated with Crohn's disease: clinical phenotype and response to biologics and Janus kinase inhibitor therapy in a large multi-center cohort.

doi:10.1093/ecco-jcc/jjag139

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Article

Orofacial granulomatosis associated with Crohn's disease: clinical phenotype and response to biologics and Janus kinase inhibitor therapy in a large multi-center cohort.

Journal of Crohn's & colitis - 3 Sept 2026

Lees Robert D, Patel Priyanka, Young Gregory, Beck Lauren, Marin Angelica Molinillo, Parkinson Daniel, Pele Laetitia, Parkes Miles, Sanderson Jeremy, Herbert Cameron, Hullah Esther, Lamb Christopher A, Mawdsley Joel, Speight Richard Ally

Abstract excerpt

BACKGROUND & AIMS: Orofacial granulomatosis (OFG) is strongly associated with Crohn's disease (CD). The CD phenotype associated with OFG is poorly defined, and there is little evidence regarding treatment. We aimed to characterize OFG-associated CD phenotypes and evaluate the response of OFG to advanced therapies in the largest cohort described to date. METHODS: We conducted a retrospective cohort study of...

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Topics

Adult
Female
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Young Adult

Biological Products

Crohn Disease

Granulomatosis, Orofacial

Infliximab

Janus Kinase Inhibitors

Phenotype

Remission Induction

Retrospective Studies

Treatment Outcome

Source

Open in PubMed Open full text

Identifiers

PMID: 42768927
DOI: 10.1093/ecco-jcc/jjag139
PMCID: PMC13594358

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