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Article

Reduced thermal sensitivity and increased opioidergic tone in the TASTPM mouse model of Alzheimer's disease.

Pain - 1 Oct 2016

Aman Yahyah, Pitcher Thomas, Simeoli Raffaele, Ballard Clive, Malcangio Marzia

Abstract excerpt

Individuals with Alzheimer's disease (AD) are in susceptible patient groups in which pain is an important clinical issue that is often underdiagnosed. However, it is unclear whether decreased pain complaints in patients with AD result from elevated pain tolerance or an impaired ability to communicate sensations. Here, we explored if AD-related pathology is present in key regions of the pain pathway and assessed...

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Source

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Identifiers

PMID: 27306045
DOI: 10.1097/j.pain.0000000000000644
PMCID: PMC5028157

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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